Search results for "Key features"
showing 10 items of 30 documents
Take a Trip Through the Plant and Fungal Transportome of Mycorrhiza
2016
International audience; Soil nutrient acquisition and exchanges through symbiotic plant–fungus interactions in the rhizosphere are key features for the current agricultural and environmental challenges. Improved crop yield and plant mineral nutrition through a fungal symbiont has been widely described. In return, the host plant supplies carbon substrates to its fungal partner. We review here recent progress on molecular players of membrane transport involved in nutritional exchanges between mycorrhizal plants and fungi. We cover the transportome, from the transport proteins involved in sugar fluxes from plants towards fungi, to the uptake from the soil and exchange of nitrogen, phosphate, p…
Preclinical models for precision oncology
2018
Precision medicine approaches have revolutionized oncology. Personalized treatments require not only identification of the driving molecular alterations, but also development of targeted therapies and diagnostic tests to identify the appropriate patient populations for clinical trials and subsequent therapeutic implementation. Preclinical in vitro and in vivo models are widely used to predict efficacy of newly developed treatments. Here we discuss whether, and to what extent, preclinical models including cell lines, organoids and tumorgrafts recapitulate key features of human tumors. The potential of preclinical models to anticipate treatment efficacy and clinical benefit is also presented,…
Chapter 6 Colon
2009
Abstract The aim of this chapter is to show the key features of adult colon stem cells and provide a useful tool for their isolation, characterization and propagation.
First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant.
2009
The first total synthesis of the potent antioxidant antiostatin A1 is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.
Analysis of health communication texts: UK press coverage of debates about assisted dying
2015
Conventionally, social researchers analyse media messages by reading text and coding it. This is time consuming and restricts many studies to small samples. Nowadays very large amounts of text are available in electronic form, offering potential insights into the health messages they contain, but which appear daunting to the analyst with limited resources using conventional methods. I explain and illustrate methods for the computer-assisted analysis of media texts, using specialised software (Wordsmith Tools and Wordstat). These allow the analyst to provide a statistical overview of the key features of texts, to compare them (looking at change over time, for example) and to select illustrat…
The expanding role of LC-MS in analyzing metabolites and degradation products of food contaminants
2008
Abstract Liquid chromatography-mass spectrometry (LC-MS) has contributed significantly in advancing research in the analysis of metabolites and degradation products of food contaminants. Of particular interest is the comprehensive application of LC-MS to discovery of degradation products and metabolites. This review, covering research published between 2003 and 2008, describes how LC-MS has been used in this field, with the majority of work dealing with target-metabolite analysis and only a small fraction using LC-MS comprehensively. In considering the significance of this topic and the potential interest in it, we briefly describe state-of-the art mass analyzers applied for it (QtrAP, QqTO…
Stationary phase modulation in liquid chromatography through the serial coupling of columns: A review
2016
Liquid chromatography with single columns often does not succeed in the analysis of complex samples, in terms of resolution and analysis time. A relatively simple solution to enhance chromatographic resolution is the modulation of the stationary phase through the serial coupling of columns. This can be implemented with any type of column using compatible elution conditions and conventional instruments. This review describes the key features of column coupling and published procedures, where two or more columns were coupled in series to solve separation problems. In all reports, the authors could not resolve their samples with single columns, whereas significant enhancement in chromatographi…
PyDSC: a simple tool to treat differential scanning calorimetry data
2020
AbstractHerein, we describe an open-source, Python-based, script to treat the output of differential scanning calorimetry (DSC) experiments, called pyDSC, available free of charge for download at https://github.com/leonardo-chiappisi/pyDSC under a GNU General Public License v3.0. The main aim of this program is to provide the community with a simple program to analyze raw DSC data. Key features include the correction from spurious signals, and, most importantly, the baseline is computed with a robust, physically consistent approach. We also show that the baseline correction routine implemented in the script is significantly more reproducible than different standard ones proposed by propriet…
Social work online: a recognition of experiences and practices in Italy
2018
‘The Internet is the fabric or our lives’ [Castells, M. (2001). The Internet Galaxy: Reflections on the Internet, Business, and Society. Oxford: Oxford University Press, p. 1] – but which are the weaves that nowadays connect Italian social workers into such a fabric? Herein we aim at answering this question through a survey of on-line resources, nodes and practices of e-Social Work in Italy. We shall be discussing ICT impact on the Italian context, and the utilization of ICT by Italian social workers, in order to build up the internal and external factors that determine the current utilization levels of these emerging tools within the professional community. A review of the major on-line so…
Ambizioni e insuccessi di alcune politiche di sviluppo locale per il Mezzogiorno. Patti territoriali e Programmi integrati territoriali (Pit)
2008
In 1997 a “new programming” was launched in Italy by the Department of development and cohesion policies in Rome. One of the key features of this new phase was the emphasis on “endogenous” local development, i.e. a development which is mainly based on local actors and productive specializations. The new programming strikingly failed to deliver its expected results. Some wrong expectations were fostered with regard to local political elites (§§ 1). A certain concept of local development is inherently flawed (§§ 2). The first failure was that of “territorial agreements” (patti territoriali), but there is a remarkable reluctancy to admit it (§§ 3). Another experience of “local” development who…